TB Research Methods, 2014

An intensive, high-level course on TB diagnostic research methods

Grant support from:

Course Slides

Day 1 (14 July 2014)
WHO-TB, DR-TB, Pediatric TB, HIV-TB

Overview – The WHO global TB research Plan - C Leinhardt [Download]

Research priorities in DR-TB -D Menzies [Download]

Pediatric TB research – barriers and progress - B Marais [Download]

HIV-TB research and global priorities - WJ Burman [Download]

Overview of study architectures - D Menzies [Download]

Day 2 (15 July 2014)
Operational Research

Operational research: what, why and how - AD Harries [Download]

Capacity building for operational research in low- and middle-income countries – the SORT IT Model - AD Harries [Download]

Principles and structure of a research protocol - AD Harries [Download]

Examples of operations research studies conducted within the Indian National TB Control Programme - S Satyanarayana [Download]

Error, Confounders and Bias - M Pai [Download]

Day 3 (16 July 2014)
Molecular epidemiology, genetic epidemiology

Molecular methods for typing and branding the tubercle bacillus - M Behr [Download]

Molecular Typing for patient, outbreak and population-level studies of TB epidemiology - M Behr [Download]

Genetic Epidemiology – A brief introduction - E Schurr [Download]

Genetic association studies in TB - E Schurr [Download]

Population selection and sample size - A Benedetti [Download]

Day 4 (17 July 2014)
Randomized Clinical Trials

Trial designs. Phase 1, 2 and 3 trials. Pragmatic and OBT designs - D Menzies [Download]

Study populations and sample size. Recruitment and randomization. Preventing bias and measurement issues - F Ahmad Khan [Download]

Details re Cluster Randomized and stepped intervention trials. Safety and ethics in trials. Adverse events and DSMB. Study oversight - G Fox [Download]

Data Analysis – primary end-points, planned and unplanned secondary analyses. Interim analyses, stopping rules - D Menzies [Download]

Data Analysis Methodology - A Benedetti [Download]

Day 5 (18 July 2014)
Economic analysis and disease modelling

Introduction to infectious disease modeling - O Oxlade [Download]

Introduction to economic analyses - K Schwartzman [Download]

How to evaluate an economic analysis - K Schwartzman [Download]

Issues and challenges in modeling TB - O Oxlade [Download]