Advanced TB Diagnostics – 6-9 March 2012

Cape Town, South Africa

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Course flyer

Day 1 – 6 March 2012

  • The global value chain for TB diagnostics and current pipeline (by M Pai) [Slides]
  • Value chain in action: Xpert MTB/RIF (by M Nicol) [Slides]
  • Beyond Xpert: What will the future look like? (by K Dheda) [Slides]
  • Value chain in action: TB serological tests (by M Pai) [Slides]
  • Types of diagnostic designs and landscape of TB dx research (by M Pai) [Slides]
  • Evaluation of reproducibility and reliability of TB diagnostics (by R van Zyl-Smit) [Slides]
  • Incremental value of new diagnostics: an overview (by M Pai) [Slides]
  • Incremental value: case study: IGRAs in HIV+ patients (by M Rangaka) [Slides]

Day 2 – 7 March 2012

  • Impact of test results on diagnostic thinking and clinical decisions: an overview (by M Pai) [Slides]
  • POC testing (by M Pai) [Slides]
  • Reference standards: Brief presentations & panel discussion
    • Microscopy studies (by A Whitelaw) [Slides]
    • Molecular assays (by M Nicol) [Slides]
    • LTBI tests (by M Pai) [Slides]
    • Pediatric TB (by H Zar) [Slides]
    • Extrapulmonary TB (by J Peter) [Slides]
  • Diagnosis of TB end-points in vaccine trials: methodological issues (by H Mahomed) [Slides]
  • Evaluation of TB biomarkers: methodological issues (by W Hanekom) [Slides]
  • Impact on patient outcomes: intro to diagnostic RCTs (by M Pai) [Slides]
  • Diagnostic RCTs: case study: Xpert MTB/RIF (by G Theron) [Slides]

Day 3 – 8 March 2012

  • Systematic reviews & meta-analyses of diagnostic accuracy (by M Pai) [Slides]
  • SR: case study 1: Oral fluid vs blood-based HIV testing (by N Pant Pai) [Slides]
  • SR: case study 2: Predictive value of IGRAs (by M Rangaka) [Slides]
  • Guideline development in TB diagnostics (by M Pai) [Slides]
  • Operational and implementation research: an overview (by M Pai) [Slides]
  • Implementation research: case study 1: Improving case detection in HIV-infected persons (by S Lawn) [Slides]
  • Implementation research: case study 2: Optimizing specimen collection in children (by H Zar) [Slides]
  • Implementation research: case study 3: Optimizing urine-based diagnostics (by J Peter) [Slides]

Day 4 – 9 March 2012

  • Modeling of TB diagnostics (by P Uys) [Slides]
  • Cost-effectiveness analyses (by E Sinanovic) [Slides]
  • Panel Discussion: Getting your study published! (by M Pai & K Dheda & S Lawn & R Wilkinson) [Slides]
  • Raising funds and finding mentorship (by R Wilkinson) [Slides]

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