Course flyer
Course agendaDay 1 – 5 July 2011
 The global value chain for TB diagnostics and current pipeline (by M Pai) [Slides]
 Value chain in action: Xpert MTB/RIF (by C Boehme) [Slides]
 Value chain in action: Serological tests (by M Pai) [Slides]
 Types of diagnostic designs and landscape of TB dx research (by M Pai) [Slides]
 Avoiding optimism bias (by M Pai) [Slides]
 The architecture of demonstration studies (by C Boehme) [Slides]
 Incremental value of new diagnostics: an overview (by M Pai) [Slides]
 Incremental value: case study 1: IGRAs in HIV+ patients (by M Rangaka) [Slides]
 Incremental value: case study 2: IGRAs in low incidence setting (by J Metcalfe) [Slides]
Day 2 – 6 July 2011
 Impact of test results on diagnostic thinking and clinical decisions: an overview (by M Pai) [Slides]
 Diagnostic thinking impact: case study 1: IGRAs in children (by D Ling) [Slides]
 Diagnostic thinking impact: case study 2: Cultures (by P Hepple) [Slides]
 Reference standards: Brief presentations & panel discussion
 Microscopy studies (by A Cattamanchi) [Slides]
 Molecular assays (by C Boehme) [Slides]
 IGRAs (by D Menzies) [Slides]
 Pediatric TB (by S Graham) [Slides]
 Extrapulmonary TB (by J Peter) [Slides]
 Statistical approaches to imperfect reference standards (latent class analyses and other approaches) (by N Dendukuri) [Slides]
 Evaluation of NAATs in the absence of a perfect goldstandard test: statistical and epidemiologic issues (by N Dendukuri) [Slides]
 Impact on patient outcomes: intro to diagnostic RCTs (by M Pai) [Slides]
 Diagnostic RCTs: case study 1: Summary of TB Dx RCTs (by J Metcalfe) [Slides]
 Diagnostic RCTs: case study 2: Xpert MTB/RIF (by J Peter) [Slides]
Day 3 – 7 July 2011
 Systematic reviews: an introduction (by M Pai) [Slides]
 Systematic reviews of diagnostic accuracy (by K Steingart) [Slides]
 SR: case study 1: Serological tests for TB (by K Steingart) [Slides]
 SR: case study 2: Predictive value of IGRAs (by M Rangaka) [Slides]
 SR: case study 3: IGRAs in healthcare workers (by A Zwerling) [Slides]
 Converting ideas into commercially viable products (by V Jonas) [Slides]
 Guideline development in TB diagnostics (by K Steingart) [Slides]
 IGRA guidelines: concordance, discordance or confusion? (by C Denkinger) [Slides]
 Operational and implementation research: an overview (by M Pai) [Slides]
 Implementation research: case study 1: Improving case detection in Uganda (by A Cattamanchi) [Slides]
 Implementation research: case study 2: Urinebased diagnostics (by E Talbot) [Slides]
 Implementation research: case study 3: Value of MODS in a high prevalence setting (by S Schumacher) [Slides]
Day 4 – 8 July 2011
 Modeling of TB diagnostics: Introduction (by O Oxlade) [Slides]
 Mathematical modeling of TB interventions: review of key papers in the field (by O Oxlade) [Slides]
 Modeling TB diagnostics: historical perspective and current state of the science (by D Dowdy) [Slides]
 Modeling TB diagnostics: challenges and future directions (by D Dowdy) [Slides]
 Costeffectiveness analysis: Introduction (by H Sohn) [Slides]
 Costing of TB diagnostics (by H Sohn & O Oxlade) [Slides]
 Methods for conducting individuallevel costeffectiveness analysis (by H Sohn) [Slides]
 Costeffectiveness analysis of TB diagnostics: challenges and future directions (by D Dowdy) [Slides]
 Getting your study published! (by J Clark) [Slides]

