Advanced TB Diagnostics – 5-8 July 2011

Montreal, Canada


Course flyer
Course agenda
Day 1 – 5 July 2011

  • The global value chain for TB diagnostics and current pipeline (by M Pai) [Slides]
  • Value chain in action: Xpert MTB/RIF (by C Boehme) [Slides]
  • Value chain in action: Serological tests (by M Pai) [Slides]
  • Types of diagnostic designs and landscape of TB dx research (by M Pai) [Slides]
  • Avoiding optimism bias (by M Pai) [Slides]
  • The architecture of demonstration studies (by C Boehme) [Slides]
  • Incremental value of new diagnostics: an overview (by M Pai) [Slides]
  • Incremental value: case study 1: IGRAs in HIV+ patients (by M Rangaka) [Slides]
  • Incremental value: case study 2: IGRAs in low incidence setting (by J Metcalfe) [Slides]

Day 2 – 6 July 2011

  • Impact of test results on diagnostic thinking and clinical decisions: an overview (by M Pai) [Slides]
  • Diagnostic thinking impact: case study 1: IGRAs in children (by D Ling) [Slides]
  • Diagnostic thinking impact: case study 2: Cultures (by P Hepple) [Slides]
  • Reference standards: Brief presentations & panel discussion
    • Microscopy studies (by A Cattamanchi) [Slides]
    • Molecular assays (by C Boehme) [Slides]
    • IGRAs (by D Menzies) [Slides]
    • Pediatric TB (by S Graham) [Slides]
    • Extrapulmonary TB (by J Peter) [Slides]
  • Statistical approaches to imperfect reference standards (latent class analyses and other approaches) (by N Dendukuri) [Slides]
  • Evaluation of NAATs in the absence of a perfect gold-standard test: statistical and epidemiologic issues (by N Dendukuri) [Slides]
  • Impact on patient outcomes: intro to diagnostic RCTs (by M Pai) [Slides]
  • Diagnostic RCTs: case study 1: Summary of TB Dx RCTs (by J Metcalfe) [Slides]
  • Diagnostic RCTs: case study 2: Xpert MTB/RIF (by J Peter) [Slides]

Day 3 – 7 July 2011

  • Systematic reviews: an introduction (by M Pai) [Slides]
  • Systematic reviews of diagnostic accuracy (by K Steingart) [Slides]
  • SR: case study 1: Serological tests for TB (by K Steingart) [Slides]
  • SR: case study 2: Predictive value of IGRAs (by M Rangaka) [Slides]
  • SR: case study 3: IGRAs in healthcare workers (by A Zwerling) [Slides]
  • Converting ideas into commercially viable products (by V Jonas) [Slides]
  • Guideline development in TB diagnostics (by K Steingart) [Slides]
  • IGRA guidelines: concordance, discordance or confusion? (by C Denkinger) [Slides]
  • Operational and implementation research: an overview (by M Pai) [Slides]
  • Implementation research: case study 1: Improving case detection in Uganda (by A Cattamanchi) [Slides]
  • Implementation research: case study 2: Urine-based diagnostics (by E Talbot) [Slides]
  • Implementation research: case study 3: Value of MODS in a high prevalence setting (by S Schumacher) [Slides]

Day 4 – 8 July 2011

  • Modeling of TB diagnostics: Introduction (by O Oxlade) [Slides]
  • Mathematical modeling of TB interventions: review of key papers in the field (by O Oxlade) [Slides]
  • Modeling TB diagnostics: historical perspective and current state of the science (by D Dowdy) [Slides]
  • Modeling TB diagnostics: challenges and future directions (by D Dowdy) [Slides]
  • Cost-effectiveness analysis: Introduction (by H Sohn) [Slides]
  • Costing of TB diagnostics (by H Sohn & O Oxlade) [Slides]
  • Methods for conducting individual-level cost-effectiveness analysis (by H Sohn) [Slides]
  • Cost-effectiveness analysis of TB diagnostics: challenges and future directions (by D Dowdy) [Slides]
  • Getting your study published! (by J Clark) [Slides]